Dr. János Madarász
associate professor
Head of the Thermal Analysis and X-ray Diffraction Group
Education
1990, Eur. Eng. (from FEANI, European Federation of National Engineering Associations); 1987, M.Sc. in chemical engineering (from Technical University of Budapest, BME); 1985, B.Sc. in chemical engineering (from Technical University of Budapest, BME);
International experiences
· 1999-2000, Guest researcher for 9 months at Shizuoka University, Faculty of Technology,
(Hamamatsu, Japan), Laboratory of Inorganic Chemistry, headed by prof. Shoji Kaneko.
· 1994-1995, Guest researcher for 9 months at Helsinki University of Technology (Espoo,
Finland) Inorganic and analytical Laboratory, headed by prof. Lauri Niinistö.
Contact information
Ch. Building, 1st Floor, Room No.117, Laboratory of X-ray Diffraction Szent Gellért tér 4, HU-1111 BudapestPhone: +36-463-1111/4047; Mobile: +36-30-2427693
Research
Two of the main fields of interest of our Research Group in Thermal Analysis and X-
ray Diffraction
1.) Elucidation and exploration of chemical and physical processes and of
intermediates, by-products and volatile species taking place during various solid-
state technological steps consisting of thermal treatments and annealings toward a
final solid product, by application of various chemical analytical methods,
especially those of thermal analysis and evolved gas analyses (DSC, TG/DTA-
EGA-MS).
2.) Exploration of binary and ternary equilibrium phase diagrams for systems
consisting of resolution agents and two chiral enantiomeric components; structural
elucidation of new diastereomeric salts forming during resolutions by fractional
crystallization; predictions to be made on various choices of potential resolution
agents in cases of particule racemic substance mixtures, all by X-ray diffraction,
FTIR spectroscopy and thermoanalytical methods.
For more information on our research projects please see our website.
Honors
BME Prof. Meisel Tibor Award, 1988.
Publications
For full list see: https://m2.mtmt.hu/gui2/?type=authors&mode=browse&sel=authors10009299 · Bánhegyi, DF; Fogassy, E; Madarász, J; Pálovics, E, Crystalline forms of 4,4’-methylenediantipyrine. Crystallographic unit cell for the anhydrous form, from laboratory powder XRD pattern by DASH program package, Periodica. Polytechn. Chem. Eng. 67(4), pp. 557–564, 2023, https://doi.org/10.3311/PPch.22950 · E. Pálovics, J. Madarász, G. Pokol, E. Fogassy, D.F. Bánhegyi, Economic Separations of Organic Acidic or Basic Enantiomeric Mixtures – A Protocol Suggestion, Int. J. Mol. Sci. 2023, 24, 846, (1-23), https://10.3390/ijms24010846 · Lévay, K; Madarász, J ; Hegedűs, L, Tuning the chemoselectivity of the Pd-catalysed hydrogenation of pyridinecarbonitriles: an efficient and simple method for preparing pyridyl- or piperidylmethylamines, Catal. Sci. Technol., 2022, 12, 2634-2648, https://10.1039/d1cy02295drsc.li/catalysis · Bánhegyi, DF; Fogassy, E; Madarász, J; Pálovics, E., Optical Resolution of Two Pharmaceutical Bases with Various Uses of Tartaric Acid Derivatives and Their Sodium Salts: Racemic Ephedrine and Chloramphenicol Base, Molecules 2022, 27, 3134., https://10.3390/molecules27103134 . · Bánhegyi, DF; Szolcsányi, D; Madarász J; Pálovics, E, Enantiomeric separation of racemic amlodipine by sequential fractional crystallization through formation of diastereomeric salt solvates and co-crystals of solvate-like compounds with specific structure – A tandem resolution, Chirality, 2022, 34, 374–395, https://10.1002/chir.23373 · Bosits, MH; Pálovics, E; Madarász, J; Fogassy, E, New Discoveries in Enantiomeric Separation of Racemic Tofisopam, J. Chem. 2019, Article No. 4980792, https://10.1155/2019/4980792 · Szeleczky, Z.; Kis-Mihály, E.; Semsey, S.; Pataki, H.; Bagi, P.; Pálovics, E.; Marosi, G.; Pokol, G.; Fogassy, E.; Madarász, J. Effect of ultrasound-assisted crystallization in the diastereomeric salt resolution of tetramisole enantiomers in ternary system with O,O’-dibenzoyl-(2R,3R)- tartaric acid., Ultrason. Sonochemistry, 2016, 32, 8-17. http://dx.doi.org/10.1016/j.ultsonch.2016.02.015 · A. D. Zodge, P. Bombicz, E. Székely, G. Pokol, J. Madarász, Structural, analytical and DSC references to resolution of 2-methoxy-2-phenylacetic acid with chiral 1-cyclohexylethylamines through gas-antisolvent precipitation, Thermochim. Acta, 648 (2017) 23-31, https://10.1016/j.tca.2016.11.017 · K. Gönczi, V. Kudar, Zs. Jászay, P. Bombicz, F. Faigl, J. Madarász, Solid state structural relation and binary melting phase diagram of (S-) and racemic 2-(2-nitro-1-phenylethyl)-1,3-diphenyl-propane-1,3-dione, Thermochim. Acta 580 (2014) 46-52, https://10.1016/j.tca.2014.01.028 · P. Thorey, P. Bombicz, I. M. Szilágyi, P. Molnár, G. Bánsághi, E. Székely, B. Simándi, L. Párkányi, G. Pokol, J. Madarász, Co-crystal of (R,R)-1,2-cyclohexanediol with (R,R)-tartaric acid, a key structure in resolution of the (±)-trans-diol by supercritical extraction, and the related ternary phase system, Thermochim. Acta 497 (2010) 129-136, https://10.1016/j.tca.2009.09.001
Teaching
· Analytical Chemistry II (Bioengineering MSc spring course)
· Pharmaceutical Analysis (Pharmaceutical Engineering MSc spring course)
· Thermal Analytical Methods (Post-diploma course)
· X-ray Analytical Methods (Post-diploma course)